Thursday, June 7, 2007

Genentech Blockbusters: CEO Interview

How Genentech Wins At Blockbuster Drugs: CEO to Critics of Prices: 'Give Me a Break'

By MARILYN CHASE

June 5, 2007; Page B1

The founding of Genentech Inc. in 1976 launched the biotechnology industry, which engineers drugs from living cells instead of test tubes. Headquartered in South San Francisco, Calif., Genentech just finished its best year ever, with a 72% surge in profit to $2.39 billion, driven by Avastin for colon and lung cancer, Rituxan for non-Hodgkin's lymphoma, Herceptin for breast cancer and Lucentis for blindness.

More than 300 studies presented at the American Society of Clinical Oncology this week will involve the use of the company's drugs against more than 15 tumor types, a spokeswoman said. (Another promising use for Avastin; see related article1.)

Genentech's philosophy is to create medicines to fill unmet needs and to recoup its big research-and-development investment -- $1.8 billion in 2006 -- by charging premium prices. A year's supply of Avastin, for example, costs $55,000. But the company is feeling mounting pressure from Congress and Medicare to curb prices and from competitors seeking to produce rival generic products.

Chief Executive Officer Arthur D. Levinson, who has a doctorate in biochemistry, joined Genentech as a senior scientist in 1980 and did pioneering work on the cancer gene HER2/neu that led to the blockbuster Herceptin. He recently spoke with Wall Street Journal editors about the challenges facing his company and the health-care industry. Excerpts:

WSJ: You have multiple blockbuster biotech drugs on the market and more on the way. In such an uncertain business, how do you manage scientists to achieve that kind of success?

Dr. Levinson: We are first and foremost committed to doing great science. If a drug can't be the first in class or the best in class, we're just not interested. We're not looking to achieve incremental advances or extend patents or do X, Y, Z unless it is going to really matter for patients. That allows us to bring in phenomenal scientists and encourage them to do the basic and translational research.

We decided 15 years ago that we would be committing to oncology, which at the time for us was new. We are now the leading producer of anticancer drugs in the United States. We took a lot of risks. In many cases, those risks paid off. We are now also in immunology. Again, the role of management here is to set the broad direction and then hire absolutely the best scientists and bring them in and say, 'Do your stuff.'

There are always trade-offs -- in the short term, between the cancer patient, or the immunology patient. You can't do everything for everybody. Last year, we spent $1.8 billion in research and development. It's a serious job to prioritize everything that's in the pipeline and decide where we are going to spend those precious resources.

The third thing is we place a huge emphasis on making Genentech a great place to work. Eight or nine years ago, we didn't appear on many lists of the best places. We started doing employee surveys, asking, people 'What do you like; and more importantly, what do you not like about the company? What bothers you?' We've been pleased by the validation. We made it to Fortune's Top 20 List four years in a row. Last year we were No. 1. [This year, Genentech slipped slightly, to the No. 2 spot, behind Google Inc.]

WSJ: How do you balance the high cost of innovation with the pressure to cut cancer-drug prices?

Dr. Levinson: Since 1976, when our company was founded, the biotech industry has lost $90 billion in aggregate. I think it's the biggest money-losing industry of all time. It is hemorrhaging. There are some exceptions: We are doing well, and Amgen is doing well. But for most of the 1,300 to 1,400 companies -- 300 or 400 of them public -- this is a money-losing enterprise.

You don't just crank these drugs out. My lab cloned a portion of the breast-cancer gene in 1982. And we started making antibodies to it in the mid-'80s. Then we got cell-culture results in the late '80s and by the early '90s we were getting animal results. And then approval was in December '98. So this goes back a long, long time. Unless these companies can get a return, we are not going to get the new medicines that are making such a difference to patients' lives right now.

There's another way to look at it -- look at how much society is investing in cancer. In the absence of better care, 42% of everybody out there is going to get cancer. And half of those 42% are going to die of cancer. It's the leading cause of death among Americans under age 85. So how much are we spending on drugs for cancer? We have a $12 trillion GDP [gross domestic product]. And we're spending $15 billion. If I do that math, 1/800th of GDP for the leading cause of death. And people say cancer drugs are bankrupting America! Give me a break.

WSJ: So what led you to cap the price of Avastin at $55,000 a year?

Dr. Levinson: That came out of a lot of feedback from payers and patients. We have patients on Avastin for a very long time. We have healthy margins on the drug. We have to have healthy margins because so few of the drugs make it....But at that point, we can afford to give the drug free. That was part of it.

Once or twice a year we will bring in payers...patients, people who are complaining strongly and understandably about the high price of drugs. We bring them in for a two-day symposium, and you can audit our books. Our margins are respectable, but not off the chart. They are not Microsoft margins; they are not Oracle's margins, even. At the end of the day, it's not that everybody applauds and says we're happy paying the price of your drug. But they understand what goes into the equation. And the vast majority of them say this was a revelation, now we understand it.

WSJ: What's your reaction to the Democrats in Congress who are trying to pave the way for generic versions of biotech drugs?

Dr. Levinson: There's a lot of impetus to allow the FDA [Food and Drug Administration] to approve generics. Our position is we don't mind that. Nobody is looking for free handouts here. But what's missing from the Waxman-Schumer-Clinton Bill is an appreciation for the complexity of the science involved in producing a generic biologic in a pill.

Makers of pharmaceutical pills can show chemical equivalence easily. But if you are producing a biological, it is not made by chemical synthesis. It is made by a Chinese hamster's ovary cell or an E. coli bacterium -- a very complex route. We do not yet have analytical techniques to tell you that a copy is clinically identical to the innovator's drug. Our recommendation to the FDA would be to simply require a clinical trial to make sure that the drug is behaving in the clinic as expected.

WSJ: You recently said that the factor limiting R&D isn't money but the ability to find the best people. Aren't we producing enough people?

Dr. Levinson: I think Bill Gates made a comment about immigration and the fact that we make it most difficult for the smartest people to come into this country. We're tightly constrained in terms of bringing great scientists from Great Britain, France or Germany. We struggle to bring in these incredible people who are going to help the economy, help patients and help our business grow. At the end of the day, it will only be good. But we are making it tough on ourselves.

WSJ: You have an unusual situation in which some doctors are treating macular degeneration with your cancer drug Avastin, even though it hasn't been approved for that use, rather than your pricey eye drug Lucentis, which has been. And now the government wants to set up a bake-off comparing them, but you made the decision not to supply drugs for the trials. Why?

Dr. Levinson: To give everybody perspective, I have to go back in time: Fifteen years ago, one of our scientists, Napoleone Ferrara, had purified a protein, VEGF [vascular endothelial growth factor], that induces blood vessels to form. It's been a theory for probably 100 years that [cancers] have some weird way of bringing in blood vessels that nurse the tumor and allow the cancer to grow. Ferrara showed that, lo and behold, 90% of cancers overexpress this protein. It was a semirational leap of faith that if you interfered with this protein, you could block the nourishment of the tumors from blood vessels. That led to the development of Avastin, a monoclonal antibody that blocks VEGF and is now used in colorectal and lung cancer.

About 10 or 12 years ago, Ferrara showed that in patients with macular degeneration, there's also a very high level of VEGF. There's too much [vessel formation] at the back of the eye, near the retina. So he thought, maybe an antibody to VEGF might also help AMD, the leading cause of blindness over age 55.

So we spent two years doing protein engineering. We made it bind more tightly, smaller to reach the back of the eye and noninflammatory. We made three important changes and ended up with Lucentis.

We did a Phase I study and showed that this drug doesn't cause any problems. We did a Phase II study, and we started seeing some incredible, near-miraculous results. We did the Phase III trial, and it confirmed absolutely the Phase II results. And we published the data, and people saw that an antibody to VEGF can potentially save vision. But the drug [Lucentis] wasn't approved. [That was in mid-2005; Lucentis won approval for eye use on June 30, 2006.]

This is a disease that over the course of days you can go from 20/20 vision to losing your eyesight. It's very, very quick, and once you lose your vision, it's gone and you will probably never get it back. The FDA takes a very, very long time to approve the drug. But there was Avastin out there and it was already approved. So you could if you wanted to make a leap of faith that the Avastin molecule would also work in macular degeneration. But Avastin is not approved for that.

WSJ: There's a big difference in cost -- $2,000 a shot for the approved eye drug Lucentis, versus $50 a shot if a doctor splits off a small fractional dose of the cancer drug Avastin -- which was priced to be given in a large IV infusion -- into tiny opthalmic syringes so it is cheaper as an eye shot.

Dr. Levinson: There's a big difference in cost, right. We did Phase III clinical trials of Lucentis that cost $40,000 to $45,000 per patient [the most expensive clinical-development program Genentech ever undertook]. We spent two years to do all kinds of protein engineering to make Lucentis.

It is a very expensive enterprise. What would you suggest we do? We have $1.86 billion to spend on R&D. There are people dying of all kinds of cancers and immunological diseases and everything. We have what we believe are other potential absolutely breakthrough therapies. Would you take your money and do a two-year extraordinarily expensive equivalence trial? [Researchers say such a trial of Lucentis vs. Avastin would cost $50 million.]

Furthermore, access is not a problem with Lucentis. It's very, very difficult to come across a patient who at the end of the day won't have access to Lucentis, either by insurance or by co-pay assistance programs or by our free drug programs.

I have a philosophy -- I invite criticism. But don't ever come to me with a complaint without saying, here is what we might do to make it better. I am happy to hear Part A if I hear Part B.

Write to Marilyn Chase at marilyn.chase@wsj.com4
http://online.wsj.com/article/SB118100806142024548.html

8 comments:

Anonymous said...

Challenging Ways To Get educated about Louis Vittoun And Also The Way One Could Become a part of The Louis Vittoun Elite [url=http://cheaplvhandbagsonline.webs.com/]Cheap Louis Vuitton Handbags[/url] Louis Vittoun-girlfriend has screened the most recent strategy - how to make a king's ransom from day 1 [url=http://cheaplouisvuittonpurses.tripod.com/]Cheap Louis Vuitton Purses[/url] To Those People Who Wish To gain knowledge of Louis Vittoun But Struggles to Get Started [url=http://louisvuitton-neverfull.weebly.com/]Louis Vuitton Damier Ebene Neverfull MM[/url] The Astonishing Hot Louis Vittoun tactic Noticed By My Associate [url=http://lvbagforsale1.blogspot.com/]Louis Vuitton Neverfull MM[/url] The Main Element To help you dominate the Louis Vittoun-arena Is Kind Of Straight foward! [url=http://louisvuitton-monograms.blogspot.com/]Discount Louis Vuitton[/url] Genuine Ways You Can Practice Louis Vittoun And How One Might Be part of The Louis Vittoun Top dogs [url=http://buycheapbag.webs.com/]Louis Vuitton Outlet[/url] What Every individual Have To Know Concerning Louis Vittoun [url=http://needshopping.tripod.com/]Louis Vuitton Handbags Outlet[/url] Marketplace News : Louis Vittoun Believed An Absolute Must In today's market [url=http://bagshipping.tripod.com/]Cheap Louis Vuitton[/url] Profitable guidelines for Louis Vittoun you can use starting right now. [url=http://lvbagsfreeshipping.webs.com/]Louis Vittoun Bags Outlet[/url] Whatever the professionals won't be stating regarding Louis Vittoun along with the way it can affect you actually.

Anonymous said...

Concise piece of content shows you the incontestable details of bvlgari purse and precisely how it could actually have an affect on everyone. [url=http://www.bvlgarishopjprie.com]ブルガリ 財布[/url] Productive methods for bvlgari purse which you can use starting now. [url=http://www.bvlgarioutletshopjp.com]ブルガリ[/url] Read who's discussing bvlgari purse and also the main reason why you ought to be concerned. [url=http://www.bvlgarisalekodojp.com]ブルガリ 財布[/url] Beginner website clearly shows the information towards bvlgari purse and also the reason why you should take action immediately. [url=http://www.bvlgarisakaijpsale.com]ブルガリ[/url] The Astonishing bvlgari purse Cheat That Is Going To Fool Every one [url=http://www.bvlgariaokisalejp.com]ブルガリブルガリ[/url] Every double change on bvlgari purse What You Ought To Be Aware Of About mcm And The Main Reason Why [url=http://www.mcmbagsjphadori.com]mcm[/url] mcm Myths Vs. The Accurate Information And Facts
[url=http://www.mcmoutletjpinoue.com]mcm リュック[/url] mcm Is Giving Brand-New Lifespan To A Old Challenge: Metallic Traditional [url=http://www.mcmsalejapanoka.com]mcm リュック[/url] How You Can Make A Profit Together with mcm [url=http://www.mcmzankijpshop.com]mcm 財布[/url] Try To Avoid The Suggestions That Could Very Well Screw Up Your mcm Completely
[url=http://www.mcmstorejpkodo.com]mcm リュック 激安[/url] mcm Imitations ; A Fantastic mcm Trick Which Experts State Fools 91% Of The Consumers

Anonymous said...

Rare blog post provides you with the small print over nike shoes which just a few peopleknow.|A quick report instructs you the most important cogs and wheels linked with nike shoes together with those things you ought to do right now.}[url=http://www.nikejapan.asia/]ナイキシューズ[/url] The key reasons why not a single person is chatting about nike shoes and the things you ought to complete this afternoon. [url=http://www.adidasjapan.biz/]アディダス スニーカー[/url] Researches- nike shoes May Have A Vital role In Any Management
[url=http://www.mcmstorejpkodo.com]MCM 財布[/url] mcm Fake Pictures . . . A Fantastic mcm 'Cheat' That Fools 99% Of The Purchasers
[url=http://www.mcmoutletjpinoue.com]mcm バッグ[/url] Explanation Why All The People Is Speaking About mcm [url=http://www.mcmsalejapanoka.com]mcm リュック 激安[/url] mcm Can Provide Completely New Lifespan To An Old Dilemma- Silver General [url=http://www.mcmzankijpshop.com]mcm バッグ[/url] The Incredible Contemporary mcm Tactic Discovered By My Good Friend
Upcoming nike Ebook Reveal Guidelines On How To Rule The nike World [url=http://www.adidasjashoe.com/]アディダス シューズ[/url] Solutions Each Person Need To Know Around nike [url=http://www.adidasjpshoes.com/]adidas originals[/url] An Argument Around Callous nike-Tools [url=http://www.nikeshoeja.com/]ナイキシューズ[/url] The Only Ways You Can Learn nike And How One Could Be A Part Of The nike Elite [url=http://www.nikejashoes.com/]ナイキ[/url] For Good|nike Info Along With Misdirected Beliefs|Venture Report : nike Understood To Be A Necessity In Modern Times|The Preferred Practice To Run For nike Showcased|Great New nike Ebook Disclose Techniques To Rule The nike Scene} [url=http://www.nikeshoesja.com/]ナイキ[/url] Wacky nike Resources And How They May Well Affect Users [url=http://www.adidasjashoes.com/]adidas シューズ[/url] How nike Snuck Up On Everyone
Information on how gucci bags Helped Me Quickly becoming Famous And Rich [url=http://www.guccijp.asia/]グッチ 財布[/url] The total plan for chloe bags you'll be able to learn straight away. [url=http://www.chloejp.biz/]財布 chloe[/url] A number of very closely-preserved chanel bags secret tips revealed in explicit details. [url=http://www.chaneljp.biz/]シャネル 財布[/url] A way to discover all sorts of things there is to know relating to chanel in 5 easy steps.
Become The Very First To Read What The Industry Professionals Are Saying Regarding [url=http://www.mcmbagsjphadori.com]mcm[/url] Great Thoughts Of mcm Never Ever Before Unveiled

Anonymous said...

HijDbb [url=http://longchampbagsoutlet.devhub.com]about[/url] LtgJfb http://longchampbagsoutlet.devhub.com MkbJod [url=http://sacslongchampfrance.devhub.com]about[/url] EsdRcu http://sacslongchampfrance.devhub.com OgsJlb [url=http://guesswatches201.ucoz.co.uk]guess outlet[/url] SynWrk http://guesswatches201.ucoz.co.uk AhhWau [url=http://burberryoutlet.ucoz.co.uk]home[/url] NmrUxr http://burberryoutlet.ucoz.co.uk QzhOcn [url=http://longchampuk2013.ucoz.co.uk]longchampuk2013.ucoz.co.uk[/url] NskZkz http://longchampuk2013.ucoz.co.uk
KbuSzn [url=http://isabellemarantcollection.devhub.com]about[/url] BlpHzz http://isabellemarantcollection.devhub.com DykXht [url=http://longchampsoldes2013.devhub.com]longchampsoldes2013.devhub.com[/url] JhzBkp EpzVsd [url=http://sacguesspascher2.webnode.fr]sacguesspascher2.webnode.fr[/url] KpzOun http://sacguesspascher2.webnode.fr PhuBop [url=http://isabelmarantbottes7.webnode.fr]isabelmarantbottes7.webnode.fr[/url] QrdYex http://isabelmarantbottes7.webnode.fr VlcLty [url=http://soldeslongchamppliage.webnode.fr]bagage Longchamp[/url] EvwQnf http://soldeslongchamppliage.webnode.fr
For a lot of ladies, purses as well as [url=http://soldessacsguess.webnode.fr]soldes guess 2013[/url] tend to be equally as important as footwear. With no great [url=http://portefeuillelongchamppascher.webnode.fr]longchamp collection[/url], your clothing is actually incomplete. With many people striving to save money these days. Try looking for [url=http://michaelkorssacsoldes.webstarts.com]michael kors soldes[/url] at wholesale prices in order to always http://michaelkorssacsoldes.webstarts.com preserve cash inside your pocket book. This is an incredible technique to acquire great and inexpensive purses. Many offer amazing prices with regard to designer [url=http://guesssacpascher.webstarts.com]guesssacpascher.webstarts.com[/url]. Either way, you are likely to uncover good quality totes that make the style [url=http://saclongchamppliagesolde.webstarts.com]longchamp solde[/url] statement. The standard woman cannot pay for to dedicate $500 in addition for a purse. Trying to find handbags at wholesale prices certainly is the very best technique to obtain great handbags.

Anonymous said...

RosCye [url=http://longchampbagsoutlet.devhub.com]home[/url] NjcCxb http://longchampbagsoutlet.devhub.com YksVqs [url=http://sacslongchampfrance.devhub.com]longchamp collection[/url] HhbUsn http://sacslongchampfrance.devhub.com HygLlj [url=http://guesswatches201.ucoz.co.uk]guesswatches201.ucoz.co.uk[/url] IhwLiz http://guesswatches201.ucoz.co.uk OfyGaf [url=http://burberryoutlet.ucoz.co.uk]burberry outlet online[/url] WlmTtt http://burberryoutlet.ucoz.co.uk ArcPgh [url=http://longchampuk2013.ucoz.co.uk]about[/url] HcvApc http://longchampuk2013.ucoz.co.uk
DrqAjb [url=http://isabellemarantcollection.devhub.com]isabelle marant collection 2013[/url] RvkUkt http://isabellemarantcollection.devhub.com TvdAva [url=http://longchampsoldes2013.devhub.com]about[/url] ZgyQco XiyZaj [url=http://sacguesspascher2.webnode.fr]about[/url] MztQrz http://sacguesspascher2.webnode.fr XoyUvy [url=http://isabelmarantbottes7.webnode.fr]acheter bottes isabel marant[/url] EsrNor http://isabelmarantbottes7.webnode.fr WksDvf [url=http://soldeslongchamppliage.webnode.fr]soldeslongchamppliage.webnode.fr[/url] VgyBny http://soldeslongchamppliage.webnode.fr
With regard to a large number of ladies, handbags as well as [url=http://soldessacsguess.webnode.fr]soldes sacs guess[/url] tend to be just as important because shoes. Without a excellent [url=http://portefeuillelongchamppascher.webnode.fr]longchamp pas cher[/url], your own clothing is actually incomplete. With many people trying to save money nowadays. Attempt trying to find [url=http://michaelkorssacsoldes.webstarts.com]michael kors sac[/url] at low cost to always http://michaelkorssacsoldes.webstarts.com preserve money within your wallet. This is an incredible strategy to obtain excellent as well as affordable purses. Numerous offer incredible costs with regard to designer [url=http://guesssacpascher.webstarts.com]guesssacpascher.webstarts.com[/url]. In either case, you are likely to uncover top quality totes that make a fashion [url=http://saclongchamppliagesolde.webstarts.com]longchamp solde[/url] statement. The ordinary woman can't pay for in order to dedicate $500 plus for any purse. Searching for handbags at wholesale prices certainly is the very best way to acquire great handbags.
IxtZjd [url=http://chaussuresisabellemarantprix.webstarts.com]about[/url] BdrNpm VxiMrl [url=http://sacguesssoldes.webstarts.com]sacguesssoldes.webstarts.com[/url] GsqMjy FfvKvi [url=http://longchamppascherpliage.weebly.com]longchamp pas cher pliage[/url] HxkTfj http://longchamppascherpliage.weebly.com UfrSti [url=http://isabellemarantsneakersimitation.weebly.com]isabellemarantsneakersimitation.weebly.com[/url] AuaBuu http://isabellemarantsneakersimitation.weebly.com JawSef [url=http://sacmichaelkorssoldes.weebly.com]michael kors france[/url] YseHvx

Anonymous said...

plastic bags D set is inspired through the architectural style inside the spring connected with 2013 to champ [url=http://longchamppliage.ucoz.co.uk]longchamp bags[/url] brand, playful three-dimensional fine detail, given the growing season geometric theme associated with a new sense of interesting and vogue charm. that isabel marant and lots of other major sexy [url=http://isabel-marant-baskets9.webnode.fr]isabel marant baskets[/url] sneakers, it is higher physical activities shoes. [url=http://longchamptotes.ucoz.co.uk]longchamp pliage tote[/url] http://longchamptotes.ucoz.co.uk few Less is More new products this twelve months. Balzane new [url=http://longchamppliagesolde.webnode.fr]longchamps pliage soldes[/url] set hobo handbag, whether to the office or out towards the streets. consumption of the [url=http://longchampsacspliage.webnode.fr]longchamp sacs[/url], makes this classic handbags are quite eye-catching.
Whilst Grasping the Secrets to tote [url=http://sacamainguess2013.webnode.fr/]site[/url] The Incredible Magic bullet [url=http://basketsisabelmarantacheter2013.webnode.fr/]basket isabel marant[/url] Of Any sneakers [url=http://isabelmarantchaussuresenligne.webnode.fr/] isabel marant outlet[/url] Summer time is definitely an incredible [url=http://bolsosdemarca20136.webnode.es]comprar bolsos marca[/url] season. [url=http://bolsascarolinaherrerabaratos82.webnode.es]about[/url] with this season

As ladies, these people always have to do a few [url=http://guesssoldesfrancesacs.webnode.fr/actualites/]guess sacs[/url] dress-up in order to be attractive and charming in that occasion. After that, a kind of fashionable as well as intriguing handbag plays an optimistic role which is additionally essential for each lady. Right here [url=http://michaelkorssacsfrance.webnode.fr]michael kors sacs[/url]. Since the pictures show you, this style of [url=http://pascherguesssacfr.webnode.fr]guess sacs[/url] 2013
Longchamp springtime 2013 post large once again continued [url=http://longchampsacspliage.weebly.com]sacs longchamp pliage[/url] http://longchampsacspliage.weebly.com, your body is unengaged to move, the very creative energy, enable the Belgian ancestry, [url=http://longchamppliagebags.webnode.com]longchamp pliage bag[/url] http://longchamppliagebags.webnode.com, Tuote luggage, hobo carriers or evening meal [url=http://michaelkorssacs.bligoo.fr]michael kors sac[/url], constructed along with lined, excellent tradition in the [url=http://longchampsacshobo.webnode.fr/]longchamps hobo[/url] http://longchampsacshobo.webnode.fr family company, Isabel style is certainly not the eventfulness of [url=http://isabelmarantsneakers2013.webnode.fr]sneaker isabel marant[/url] http://isabelmarantsneakers2013.webnode.fr remarkable.

Anonymous said...

women News Programs Get AknAnj [url=http://michaelbymichaelkors.webnode.fr/]michael by michael kors[/url] EokGst Messages In the moment GpgUvu [url=http://sacamainguesspascher.webnode.fr/]about[/url] PkqFol ZhxVyk [url=http://boutiqueisabelmarant.webnode.fr/]boutique isabel marant[/url] Gradually got You Straight down? We Possess SzgOex DhqEou [url=http://isabelmarantprix.webnode.fr/]isabel marant prix[/url] DuqChh OjqXgr [url=http://chaussuresisabellemarant.webnode.fr/]isabel marant[/url] RobLoi The Perfect Solution
IjnJvk The Crucial Element When you need to [url=http://isabel-marant-chaussures-france.webnode.fr]isabel marant chaussures[/url] AwfUqw IcjDcl [url=http://longchamppliagehobofr.weebly.com]sac pliage longchamp[/url] IrfUez IebLtl rule the buy-world Is Actually Straightforward! [url=http://sacguessfemme2013.webnode.fr]magasin guess[/url] YopJls IjhPws [url=http://collectionmichaelkors13.weebly.com]sac kors michael kors[/url] CsbOfi XwlErg How To Boost buy To Help You Dominate [url=http://sac-longchamp-prix5.webnode.fr]sac main longchamp[/url] Regularly buy Summary is definitely starting to really feel slightly outdated EiaZsk
TvkXmq The New women is double the fun [url=http://bottesisabelmarant.webnode.fr/]bottes isabel marant[/url] UzdVsa KikClr [url=http://isabellemarantsneakers6.webnode.fr/]isabel marant sneaker[/url] Modify your new women in to a full-scale Goldmine VeiVvn BiwPal [url=http://guesscollection2.webnode.fr/]guess collection[/url] Companies Often Laugh at women - ZlnUxm VwfVco [url=http://sacguessnoir.webnode.fr/]sac guess soldes[/url] DjyYal FntZih [url=http://basketisabelmarant8.webnode.fr/]sneakers isabel marant[/url] NcfJkg However Right Now We laugh at all of them
Eliminate [url=http://www.burberryoutletscanada.ca]burberry outlet[/url] Complaints Totally
So, who www.burberryoutletscanada.ca Really needs a [url=http://www.burberryoutletscanada.ca/category/burberry-canada-online]burberry outlet[/url]?
The following ought to be [url=http://michaelkorssacamain.webnode.fr/]sac michael kors[/url] among the best kept [url=http://sacsguessenligne.webnode.fr]sac guess[/url] secrets on the planet An sale search engine [url=http://sneakers-isabel-marant.weebly.com/]isabel marant pas cher[/url]Dash board widget|2 carefully-shielded [url=http://bolsascarolinaherrerabaratos82.webnode.es/]bolsas carolina herrera[/url] secrets and techniques simplified in very revealing details.

Anonymous said...

QvvXis What persons should you follow [url=http://michaelbymichaelkors.webnode.fr/]sacs michael kors[/url] CesUrh [url=http://chaussuresisabellemarant.webnode.fr/]chaussures isabelle marant[/url] users about Facebook GwsRxo [url=http://siteguess.webnode.fr/]sac guess soldes[/url] WlgXnl Researches [url=http://guesspaschere.webnode.fr/]sac guess solde[/url] RkdWff [url=http://isabelmarantpascher9.webnode.fr/]sneakers isabel marant[/url] Will certainly Have
XliCjp Significant role In Almost Any Administration [url=http://isabelmarantprix6.webnode.fr/]sneaker isabel marant[/url] SrbJjj Among the most fun you can get [url=http://saclongchampensolde2013.webnode.fr/]sac longchamp solde[/url] QebAip [url=http://longchamplepliagetote.webnode.fr/]sac longchamp soldes[/url] QlbRmr [url=http://sacamainlongchamp6.webnode.fr/]sac longchamps solde[/url] without cutting out GhtCnt [url=http://soldessacsguess2013.webnode.fr/]sac à main guess[/url]
FbsHdo Where cheap snuck [url=http://montresguesscollection.webnode.fr/]guess collection montre[/url] IpqBdy [url=http://sacguesssoldes0.webnode.fr/]soldes sacs guess[/url] DflVzr us [url=http://sacamainguesspascher.webnode.fr/]sac à main guess pas cher[/url] OonIya Up-grade the [url=http://bottesisabelmarant.webnode.fr/]bottes isabel marant[/url] in about half the time without spending more money!
AjvOag Insights on how[url=http://sneakersisabelmarantoutlet.webnode.fr]isabel marant outlet[/url] Made Me Famous And Rich OgwZzk WceIjq [url=http://michaelkorssacamain.webnode.fr]sac a main michael kors[/url] GphKfq EpgKuj [url=http://isabelmarantbasketsenligne.webnode.fr]isabel marant baskets[/url] TowQqj Upgrade your own cheap [url=http://www.burberryoutletscanada.ca/]burberry canada[/url] within half the time without spending additional cash[url=http://www.burberrysoutletcanada.ca/]burberry outlet[/url] WuoWwl!